Article
A desensitization-inhibiting mutation in the glutamate binding site of rat alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is dominant in heteromultimeric complexes.
Neuroscience letters - 31 Dec 1999
Thalhammer A, Morth T, Strutz N, Hollmann M
Abstract excerpt
Recently, it has been shown that a single leucine-to-tyrosine mutation in the agonist binding domains of the homomerically expressed alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors GluR3 and GluR1 is sufficient to completely block receptor desensitization. In the present study we tested heteromeric subunit combinations of AMPA receptors to demonstrate that the block of desensitization...
Topics
- Amino Acid Sequence
- Animals
- Benzothiadiazines
- Binding Sites
- Female
- Genes, Dominant
- Glutamic Acid
- Mutation
- Oocytes
- Protein Isoforms
- RNA Editing
- Rats
- Receptors, AMPA
- Xenopus laevis