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Article

Site within N-Methyl-D-aspartate receptor pore modulates channel gating.

Molecular pharmacology - 1 Jan 2004

Chen Nansheng, Li Bo, Murphy Timothy H, Raymond Lynn A

Abstract excerpt

N-methyl-d-aspartate-type glutamate receptors (NMDARs) are ligand-gated ion channels activated by coagonists glutamate and glycine. NMDARs play a critical role in synaptic plasticity and excitotoxicity, largely because of their high calcium permeability and slow deactivation and desensitization kinetics. NR1 is an obligate subunit in all NMDAR complexes, where it combines with NR2A, 2B, 2C, and/or 2D. NR1 binds...

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Identifiers

PMID: 14722247
DOI: 10.1124/mol.65.1.157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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