Article
A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2. A mutagenic, kinetic, and crystallographic study.
The Journal of biological chemistry - 21 Oct 2005
Holm Mai Marie, Naur Peter, Vestergaard Bente, Geballe Matthew T, Gajhede Michael, Kastrup Jette S, Traynelis Stephen F, Egebjerg Jan
Abstract excerpt
Binding of an agonist to the 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)-propionic acid (AMPA) receptor family of the glutamate receptors (GluRs) results in rapid activation of an ion channel. Continuous application results in a non-desensitizing response for agonists like kainate, whereas most other agonists, such as the endogenous agonist (S)-glutamate, induce desensitization. We demonstrate that a highly...
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