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Article

AMPA receptor desensitization mutation results in severe developmental phenotypes and early postnatal lethality.

Proceedings of the National Academy of Sciences of the United States of America - 18 May 2010

Christie Louisa A, Russell Theron A, Xu Jian, Wood Lydia, Shepherd Gordon M G, Contractor Anis

Abstract excerpt

AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate) recep-tors desensitize rapidly and completely in the continued presence of their endogenous ligand glutamate; however, it is not clear what role AMPA receptor desensitization plays in the brain. We generated a knock-in mouse in which a single amino acid residue, which controls desensitization, was mutated in the GluA2 (GluR2) receptor subunit...

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Identifiers

PMID: 20439731
DOI: 10.1073/pnas.0908206107
PMCID: PMC2889074

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Source receipt: pubmed, retrieved 7 Sept 2026.

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