Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide.

doi:10.1038/71901

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Article

Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide.

Nature biotechnology - 1 Jan 2000

Alexeev V, Igoucheva O, Domashenko A, Cotsarelis G, Yoon K

Abstract excerpt

We recently demonstrated that an RNA-DNA oligonucleotide corrected a point mutation in the mouse tyrosinase gene, resulting in permanent and inheritable restoration of tyrosinase enzymatic activity, melanin synthesis, and pigmentation changes in cultured melanocytes. In this study, we extended gene correction of melanocytes from tissue culture to live animals, using a chimeric oligonucleotide designed to correct...

Topics

Administration, Cutaneous
Albinism
Amino Acid Sequence
Animals
Base Sequence
Chromosomes
DNA
Gene Conversion
Genetic Therapy
Hair Color
Hair Follicle
Injections, Intradermal
Melanocytes
Mice
Mice, Inbred BALB C

Source

Open in PubMed

Identifiers

PMID: 10625389
DOI: 10.1038/71901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Molecular Sequence Data

Monophenol Monooxygenase

Oligonucleotides