Article
Chimeric RNA/DNA oligonucleotide-based gene therapy.
Kidney international - 1 Jan 2002
Lai Li-Wen, Lien Yeong-Hau H
Abstract excerpt
BACKGROUND: Chimeric RNA/DNA oligonucleotides, emerging as a potential strategy for gene therapy, have been shown to induce site-specific correction of point mutations in several genetic disease models. METHODS: Six recent studies of chimeric RNA/DNA oligonucleotide-based gene therapy in genetic disease models are reviewed. Chimeric RNA/DNA oligonucleotides, complementary to 25 to 30 residues of genomic DNA...
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