Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide.

doi:10.1038/4322

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Article

Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide.

Nature biotechnology - 1 Dec 1998

Alexeev V, Yoon K

Abstract excerpt

Experimental strategies have been developed to correct point mutations using chimeric oligonucleotides composed of RNA and DNA. We used these RNA-DNA oligonucleotides to correct a point mutation in mouse tyrosinase, a key enzyme for melanin synthesis and pigmentation. Melanocytes derived from alb...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Line
DNA
Genotype
Melanocytes
Mice
Molecular Sequence Data
Monophenol Monooxygenase
Nucleic Acid Hybridization
Phenotype
Pigmentation
Point Mutation
RNA

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