Article
Molecular basis of dark-eyed albinism in the mouse.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 1994
Schmidt A, Beermann F
Abstract excerpt
Dark-eyed albino (C44H) is a recessive allele at the mouse albino (c) locus, which encodes tyrosinase (monophenol,L-dopa:oxygen oxidoreductase, EC 1.14.18.1), the key enzyme in melanin synthesis. Similar to type IB oculocutaneous albinism in humans, overall production of pigment is greatly reduced in dark-eyed albino mice and obvious only in the eyes. We have studied the molecular basis of the c44H mutation and...
Topics
- Albinism
- Animals
- Base Sequence
- DNA
- Eye Color
- Genes, Recessive
- Homozygote
- Humans
- Melanins
- Mice
- Mice, Transgenic
- Molecular Sequence Data