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Article

A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine----serine substitution at position 85.

European journal of biochemistry - 30 Apr 1990

Shibahara S, Okinaga S, Tomita Y, Takeda A, Yamamoto H, Sato M, Takeuchi T

Abstract excerpt

Murine albinism is characterized by complete lack of melanin pigments in skin and retina. In order to study the molecular basis of albinism, we have cloned and characterized the tyrosinase gene of BALB/c mice (c/c). Sequence analysis of this gene reveals a point mutation at nucleotide residue 387 (G----C transversion) causing a Cys----Ser substitution at position 85 in one of the cysteine-rich domains of the...

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PMID: 2110899
DOI: 10.1111/j.1432-1033.1990.tb15510.x

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