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Stable and full rescue of the pigmentation in a medaka albino mutant by transfer of a 17 kb genomic clone containing the medaka tyrosinase gene.

Gene - 11 Jan 2000

Fu L, Mambrini M, Perrot E, Chourrout D

Abstract excerpt

In the medaka Oryzias latipes, several albino strains have mutations in the tyrosinase gene that have been fully characterized at the molecular level. A genomic clone from wild-type medaka containing the 5 kb tyrosinase gene with its five exons, 10 kb of upstream sequences and 2 kb downstream sequences was introduced into fertilized eggs from a tyrosinase-negative albino strain. We show that the injection of this...

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PMID: 10675031
DOI: 10.1016/s0378-1119(99)00473-4

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