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Article

The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2007

Mihai Sidonia, Chiriac Mircea T, Takahashi Kazue, Thurman Joshua M, Holers V Michael, Zillikens Detlef, Botto Marina, Sitaru Cassian

Abstract excerpt

Epidermolysis bullosa acquisita is a subepidermal blistering disease associated with tissue-bound and circulating autoantibodies against type VII collagen, a major constituent of the dermal-epidermal junction. The passive transfer of Abs against type VII collagen into mice induces a subepidermal blistering disease dependent upon activation of terminal complement components. To further dissect the role of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17475881
DOI: 10.4049/jimmunol.178.10.6514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita.PMID 17475881Read ↗

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