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Article

Abrogation of the alternative complement pathway by targeted deletion of murine factor B

5 Aug 1997

Abstract excerpt

To investigate the role of complement protein factor B (Bf) and alternative pathway activity in vivo, and to test the hypothesized potential genetic lethal effect of Bf deficiency, the murine Bf gene was interrupted by exchange of exon 3 through exon 7 (including the factor D cleaving site) with the neor gene. Mice heterozygous for the targeted Bf allele were interbred, yielding Bf-deficient offspring after the...

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Identifiers

PMID: 9238044
DOI: 10.1073/pnas.94.16.8720

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