FcRγ promotes T cell apoptosis in Fas-deficient mice.

Abstract excerpt

Deficiency of Fas or its ligand leads to lymphocyte accumulation, lymphadenopathy, splenomegaly, and autoimmunity in mice and humans. Although the Fas pathway is important for limiting the number of peripheral T cells, inactivation of other pro-apoptotic molecules can also perturb T cell homeostasis independently of and/or in concert with Fas deficiency. Here, we show that combined deficiency of Fas and the Fc...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CD8 Antigens
• Share to Autoimmune Lymphoproliferative Syndrome
• Share to Caspase 3