Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse model.

Abstract excerpt

The immune response is regulated not only by the proliferation, differentiation, and activation of cells, but also by programmed cell death, called apoptosis. Fas ligand expressed in activated T cells binds to its receptor, Fas, and induces apoptosis in target cells. Two mouse mutations that caus...

Topics

• Amino Acid Sequence
• Animals
• Apoptosis
• Autoimmune Diseases
• B-Lymphocytes
• Base Sequence
• DNA
• Disease Models, Animal
• Fas Ligand Protein
• Humans
• Lymphoproliferative Disorders
• Membrane Glycoproteins
• Mice
• Mice, Inbred MRL lpr
• Molecular Sequence Data
• Mutation
• Syndrome
• T-Lymphocytes