Article
Paraoxonase activity in two healthy populations with differing rates of coronary heart disease.
European journal of clinical investigation - 1 Jan 2000
MacKness B, Mackness M I, Durrington P N, Arrol S, Evans A E, McMaster D, Ferrières J, Ruidavets J B, Williams N R, Howard A N
Abstract excerpt
BACKGROUND: The rate of coronary heart disease is over three-fold greater in Belfast than in Toulouse and the excess risk cannot be totally explained by 'classical' risk factors such as total cholesterol, LDL-cholesterol, smoking, etc. DESIGN: The effect of the human serum paraoxonase (PON1) 192-genetic polymorphism on plasma lipid and lipoprotein concentrations and on PON1 activity and concentration was...
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