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Article

Dietary modifications and gene polymorphisms alter serum paraoxonase activity in healthy women.

The Journal of nutrition - 1 Oct 2002

Rantala Maire, Silaste Marja-Leena, Tuominen Anu, Kaikkonen Jari, Salonen Jukka T, Alfthan Georg, Aro Antti, Kesäniemi Y Antero

Abstract excerpt

Paraoxonase-1 (PON1), a HDL-associated enzyme, may protect against the development of atherosclerosis. Serum PON1 activity and PON1-mediated capacity of HDL to prevent lipoprotein oxidation are modulated by two common polymorphisms at positions 192 (Gln-->Arg) and 55 (Leu-->Met) of the PON1 gene. We studied the effect of dietary modifications on PON1 activity and the role of PON1 gene polymorphisms in the...

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Source

Identifiers

PMID: 12368388
DOI: 10.1093/jn/131.10.3012

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Dietary modifications and gene polymorphisms alter serum paraoxonase activity in healthy women.PMID 12368388Read ↗

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The effect of the paraoxonase 1 (PON1) T(-107)C polymorphism on serum PON1 activity in women is dependent on fatty acid intake.Semantic proximity Read ↗

Paraoxonase activity in two healthy populations with differing rates of coronary heart disease.Semantic proximity Read ↗

Paraoxonase 1 Q192R (PON1-192) polymorphism is associated with reduced lipid peroxidation in healthy young men on a low-carotenoid diet supplemented with tomato juice.Semantic proximity Read ↗

Determinants of paraoxonase activity in healthy adults.Semantic proximity Read ↗

Interaction between the Gln-Arg 192 variants of the paraoxonase gene and oleic acid intake as a determinant of high-density lipoprotein cholesterol and paraoxonase activity.Semantic proximity Read ↗

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The paraoxonase-1 codon 192 polymorphism is associated with fasting total cholesterol and LDL-cholesterol concentrations only in postmenopausal women. The REGICOR study.Semantic proximity Read ↗

Paraoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance.Semantic proximity Read ↗

Paraoxonase1-192 polymorphism modulates the effects of regular and acute exercise on paraoxonase1 activity.Semantic proximity Read ↗

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