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Article

Protein kinase G signaling disrupts Rac1-dependent focal adhesion assembly in liver specific pericytes.

American journal of physiology. Cell physiology - 1 Jul 2011

Routray Chittaranjan, Liu Chunsheng, Yaqoob Usman, Billadeau Daniel D, Bloch Kenneth D, Kaibuchi Kozo, Shah Vijay H, Kang Ningling

Abstract excerpt

Nitric oxide (NO) regulates the function of perivascular cells (pericytes), including hepatic stellate cells (HSC), mainly by activating cGMP and cGMP-dependent kinase (PKG) via NO/cGMP paracrine signaling. Although PKG is implicated in integrin-mediated cell adhesion to extracellular matrix, whether or how PKG signaling regulates the assembly of focal adhesion complexes (FA) and migration of HSC is not known....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21451103
DOI: 10.1152/ajpcell.00038.2011
PMCID: PMC3129819

Genes

VASP
IQGAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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