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Article

Modulation of prosurvival signaling in fibroblasts by a protein kinase inhibitor protects against fibrotic tissue injury.

The American journal of pathology - 1 Feb 2005

Vittal Ragini, Horowitz Jeffrey C, Moore Bethany B, Zhang Hengmin, Martinez Fernando J, Toews Galen B, Standiford Theodore J, Thannickal Victor J

Abstract excerpt

Progressive fibrotic diseases involving diverse organ systems are associated with the persistence of fibroblasts/myofibroblasts in injured tissues. Activation of focal adhesion kinase (FAK) and protein kinase B (PKB/Akt) by transforming growth factor-beta1 mediate stable induction of myofibroblast differentiation and survival. In this report, we demonstrate that transforming growth factor-beta1-induced activation...

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Source

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Identifiers

PMID: 15681821
DOI: 10.1016/S0002-9440(10)62260-2
PMCID: PMC1602319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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