Article
Inhibitory effect of soluble PDGF-beta receptor in culture-activated hepatic stellate cells.
Biochemical and biophysical research communications - 30 Apr 2004
Borkham-Kamphorst Erawan, Stoll Doris, Gressner Axel M, Weiskirchen Ralf
Abstract excerpt
Following liver injury, hepatic stellate cells undergo phenotypic transformation with acquisition of myofibroblast-like features, characterized by increased cell proliferation, motility, contractility, and extracellular matrix production. Activation of hepatic stellate cells is regulated by several cytokines and growth factors, including platelet-derived growth factor B-chain, a potent mitogen for HSC,...
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