Article
Genotype-phenotype correlations in attenuated adenomatous polyposis coli.
American journal of human genetics - 1 Jun 1998
Soravia C, Berk T, Madlensky L, Mitri A, Cheng H, Gallinger S, Cohen Z, Bapat B
Abstract excerpt
Germ-line mutations of the tumor suppressor APC are implicated in attenuated adenomatous polyposis coli (AAPC), a variant of familial adenomatous polyposis (FAP). AAPC is recognized by the occurrence of <100 colonic adenomas and a later onset of colorectal cancer (age >40 years). The aim of this...
Topics
- Adenomatous Polyposis Coli
- Adenomatous Polyposis Coli Protein
- Adult
- Aged
- Aged, 80 and over
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Cytoskeletal Proteins
- DNA Mutational Analysis
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Mutation
- Phenotype