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Article

Multiple APC mutations in sporadic flat colorectal adenomas.

European journal of human genetics : EJHG - 1 Dec 1999

van Wyk R, Slezak P, Kotze M J, Jaramillo E, Koizumi K, Grobbelaar J J

Abstract excerpt

Adenomas are established pre-malignant lesions in colorectal carcinogenesis. To date the adenoma-carcinoma sequence for the development of colorectal carcinoma (CRC) has been based largely on molecular data of exophytic, polypoid-type adenomas. Subsequently, a different type of adenoma has been identified: the flat adenoma, so called for its flat, non-exophytic appearance, making it less likely to be detected...

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Identifiers

PMID: 10602369
DOI: 10.1038/sj.ejhg.5200386

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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