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Article

Comprehensive mutation analysis in colorectal flat adenomas.

PloS one - 1 Jan 2012

Voorham Quirinus J M, Carvalho Beatriz, Spiertz Angela J, Claes Bart, Mongera Sandra, van Grieken Nicole C T, Grabsch Heike, Kliment Martin, Rembacken Bjorn, van de Wiel Mark A, Quirke Philip, Mulder Chris J J, Lambrechts Diether, van Engeland Manon, Meijer Gerrit A

Abstract excerpt

BACKGROUND: Flat adenomas are a subgroup of colorectal adenomas that have been associated with a distinct biology and a more aggressive clinical behavior compared to their polypoid counterparts. In the present study, we aimed to compare the mutation spectrum of 14 cancer genes, between these two phenotypes. METHODS: A consecutive series of 106 flat and 93 polypoid adenomas was analyzed retrospectively for...

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Source

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Identifiers

PMID: 22848674
DOI: 10.1371/journal.pone.0041963
PMCID: PMC3407043

Genes

APC
BRAF
CTNNB1
KRAS
NRAS
EGFR
PDGFRA
PTEN
SMAD4
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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