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Article

Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators.

Proceedings of the National Academy of Sciences of the United States of America - 21 Dec 1999

An J, Ribeiro R C, Webb P, Gustafsson J A, Kushner P J, Baxter J D, Leitman D C

Abstract excerpt

The tumor necrosis factor-alpha (TNF-alpha) promoter was used to explore the molecular mechanisms of estradiol (E(2))-dependent repression of gene transcription. E(2) inhibited basal activity and abolished TNF-alpha activation of the TNF-alpha promoter. The E(2)-inhibitory element was mapped to the -125 to -82 region of the TNF-alpha promoter, known as the TNF-responsive element (TNF-RE). An AP-1-like site in the...

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Identifiers

PMID: 10611355
DOI: 10.1073/pnas.96.26.15161
PMCID: PMC24790

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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