Article
Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology.
The Journal of biological chemistry - 20 Mar 1998
Norris J D, Fan D, Stallcup M R, McDonnell D P
Abstract excerpt
The human estrogen receptor (ER) contains two major activation functions (AFs) responsible for its transcriptional activity. One of these, activation function 2 (AF-2), located within the hormone-binding domain (HBD), has been shown to mediate the ligand-dependent transcriptional activity of ER as well as other members of the nuclear receptor superfamily. Recently, proteins interacting with the HBD of several...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.