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Article

E2F-1 Regulates Nuclear Factor-κB Activity and Cell Adhesion

18 Nov 2002

Abstract excerpt

BACKGROUND: The transcription factor E2F-1 promotes vascular smooth muscle cell apoptosis and is reported to inhibit apoptosis induced by tumor necrosis factor (TNF)-alpha in endothelial cells. Whether E2F-1 overexpression exerts potentially antiinflammatory effects in endothelial cells is not known. METHODS AND RESULTS: By immunoblotting and immunofluorescence, TNF-alpha treatment of human aortic endothelial...

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PMID: 12438297
DOI: 10.1161/01.cir.0000038706.30661.86

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