Article
Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases.
Molecular and cellular biology - 1 Jul 2005
Kumar Ajay, Lin Zhiyong, SenBanerjee Sucharita, Jain Mukesh K
Abstract excerpt
Activation of the endothelium by inflammatory cytokines is a key event in the pathogenesis of vascular disease states. Proinflammatory cytokines repress the expression of KLF2, a recently identified transcriptional inhibitor of the cytokine-mediated activation of endothelial cells. In this study the molecular basis for the cytokine-mediated inhibition of KLF2 is elucidated. Tumor necrosis factor alpha (TNF-alpha)...
Topics
- Cells, Cultured
- DNA-Binding Proteins
- Endothelium, Vascular
- Histone Deacetylases
- Humans
- Kruppel-Like Transcription Factors
- MEF2 Transcription Factors
- Mutation
- Myogenic Regulatory Factors
- NF-kappa B