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Article

Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1999

Kouba D J, Chung K Y, Nishiyama T, Vindevoghel L, Kon A, Klement J F, Uitto J, Mauviel A

Abstract excerpt

Among its plethora of activities as an inflammatory mediator, TNF-alpha has potent regulatory control on extracellular matrix production and degradation. Earlier studies have documented that TNF-alpha inhibits type I collagen gene (COL1A2) expression at the transcriptional level, but the characte...

Topics

Carrier Proteins
Cells, Cultured
Collagen
Fibroblasts
Gene Expression Regulation
Humans
Mutation
NF-kappa B
Promoter Regions, Genetic
Protein Binding
Response Elements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 10201951

Genes

TNF
CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10201951-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts.PMID 10201951Read ↗

Nuclear Factor-κB Mediates TNF-α Inhibitory Effect on α2(I) Collagen (COL1A2) Gene Transcription in Human Dermal FibroblastsSemantic proximity Read ↗

An AP-1 Binding Sequence Is Essential for Regulation of the Human α2(I) Collagen (COL1A2) Promoter Activity by Transforming Growth Factor-βSemantic proximity Read ↗

Distinct involvement of the Jun‐N‐terminal kinase and NF‐κB pathways in the repression of the human COL1A2 gene by TNF‐αSemantic proximity Read ↗

Transcriptional control of the TNF gene.Semantic proximity Read ↗

Cell-specific Induction of Distinct Oncogenes of the Jun Family Is Responsible for Differential Regulation of Collagenase Gene Expression by Transforming Growth Factor-β in Fibroblasts and KeratinocytesSemantic proximity Read ↗

Collagen alpha1(I) gene contains an element responsive to tumor necrosis factor-alpha located in the 5' untranslated region of its first exon.Semantic proximity Read ↗

Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases.Semantic proximity Read ↗

Pathway-specific Profiling Identifies the NF-κB-dependent Tumor Necrosis Factor α-regulated Genes in Epidermal KeratinocytesSemantic proximity Read ↗

Transcriptional regulation of the human α2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseasesSemantic proximity Read ↗

NF-κB accumulation associated with COL1A1 transactivators defects during chronological aging represses type I collagen expression through a -112/-61-bp region of the COL1A1 promoter in human skin fibroblasts.Semantic proximity Read ↗

IL-10 inhibits transcription elongation of the human <i>TNF</i> gene in primary macrophagesSemantic proximity Read ↗

GCF2/LRRFIP1 represses tumor necrosis factor alpha expression.Semantic proximity Read ↗

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