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Nuclear Factor-κB Mediates TNF-α Inhibitory Effect on α2(I) Collagen (COL1A2) Gene Transcription in Human Dermal Fibroblasts

1999-04-01

Abstract excerpt

Abstract Among its plethora of activities as an inflammatory mediator, TNF-α has potent regulatory control on extracellular matrix production and degradation. Earlier studies have documented that TNF-α inhibits type I collagen gene (COL1A2) expression at the transcriptional level, but the characterization of the transcription factors involved has been elusive. In the present study, using transient cell transfectio...

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Literature Corpus work
8fe9792e-2128-5bab-8c00-4fb8648e317f
DOI
10.4049/jimmunol.162.7.4226
Open publication

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Nuclear Factor-κB Mediates TNF-α Inhibitory Effect on α2(I) Collagen (COL1A2) Gene Transcription in Human Dermal FibroblastsDOI 10.4049/jimmunol.162.7.4226
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