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Article

Tumour necrosis factor and PI3-kinase control oestrogen receptor alpha protein level and its transrepression function.

British journal of cancer - 23 Feb 2004

Bhat-Nakshatri P, Campbell R A, Patel N M, Newton T R, King A J, Marshall M S, Ali S, Nakshatri H

Abstract excerpt

Oestrogen receptor alpha (ERalpha) is an oestrogen-activated transcription factor, which regulates proliferation and differentiation of mammary epithelial cells by activating or repressing gene expression. ERalpha is a critical prognostic indicator and a therapeutic target for breast cancer. Patients with tumours that express higher level of ERalpha have better prognosis than patients with tumours that are...

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Identifiers

PMID: 14970864
DOI: 10.1038/sj.bjc.6601541
PMCID: PMC2410160

Genes

MTA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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