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Article

Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.

Molecular and cellular biology - 1 Jan 2000

Lee R J, Albanese C, Fu M, D'Amico M, Lin B, Watanabe G, Haines G K, Siegel P M, Hung M C, Yarden Y, Horowitz J M, Muller W J, Pestell R G

Abstract excerpt

The neu (c-erbB-2) proto-oncogene encodes a tyrosine kinase receptor that is overexpressed in 20 to 30% of human breast tumors. Herein, cyclin D1 protein levels were increased in mammary tumors induced by overexpression of wild-type Neu or activating mutants of Neu in transgenic mice and in MCF7 cells overexpressing transforming Neu. Analyses of 12 Neu mutants in MCF7 cells indicated important roles for specific...

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Identifiers

PMID: 10611246
DOI: 10.1128/MCB.20.2.672-683.2000
PMCID: PMC85165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.PMID 10611246Read ↗

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Distinct ErbB-2 coupled signaling pathways promote mammary tumors with unique pathologic and transcriptional profiles.Semantic proximity Read ↗

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PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.Semantic proximity Read ↗

Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers.Semantic proximity Read ↗

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer.Semantic proximity Read ↗

The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice.Semantic proximity Read ↗

Specific protection against breast cancers by cyclin D1 ablation.Semantic proximity Read ↗

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HER‐2/ <i>neu</i> Signal Transduction in Human Breast and Ovarian CancerSemantic proximity Read ↗

ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events.Semantic proximity Read ↗

Oncogenic activating mutations in the neu/erbB-2 oncogene are involved in the induction of mammary tumors.Semantic proximity Read ↗

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