Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice.

Cancer research - 15 May 2008

Fereshteh Mark P, Tilli Maddalena T, Kim Sung Eun, Xu Jianming, O'Malley Bert W, Wellstein Anton, Furth Priscilla A, Riegel Anna T

Abstract excerpt

Overexpression of the oncogene amplified in breast cancer 1 (AIB1)/steroid receptor coactivator-3 (SRC-3) induces mammary tumorigenesis in mice. In breast cancer, high levels of AIB1/SRC-3 and the growth factor receptor HER2/neu predict resistance to endocrine therapy and poor outcome. However, a mechanistic relationship between AIB1/SRC-3 and HER2/neu in the development of breast cancer has not been shown. Here,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelium
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histone Acetyltransferases

Share to Mammary Neoplasms, Animal

Share to MAP Kinase Kinase 4

Share to Phosphorylation

Share to Receptor, ErbB-2

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 18483252
DOI: 10.1158/0008-5472.CAN-07-6702
PMCID: PMC3641830

Genes

SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice.PMID 18483252Read ↗

SRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor CoactivatorSemantic proximity Read ↗

Overexpression of an N-terminally truncated isoform of the nuclear receptor coactivator amplified in breast cancer 1 leads to altered proliferation of mammary epithelial cells in transgenic mice.Semantic proximity Read ↗

Critical Roles of SRC-3 in Development and Progression of Breast Cancer, Render it a Prospective Clinical TargetSemantic proximity Read ↗

Generation and validation of a mouse line with a floxed SRC-3/AIB1 allele for conditional knockout.Semantic proximity Read ↗

Steroid receptor coactivator-3 as a potential molecular target for cancer therapySemantic proximity Read ↗

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer.Semantic proximity Read ↗

Distinct ErbB-2 coupled signaling pathways promote mammary tumors with unique pathologic and transcriptional profiles.Semantic proximity Read ↗

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer.Semantic proximity Read ↗

The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease.Semantic proximity Read ↗

The Function of Steroid Receptor Coactivator-1 in Normal Tissues and CancerSemantic proximity Read ↗

The role of SRC-3 in human breast cancerSemantic proximity Read ↗

ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.