Article
Specific protection against breast cancers by cyclin D1 ablation.
Nature - 28 Jun 2001
Yu Q, Geng Y, Sicinski P
Abstract excerpt
Breast cancer is the most common malignancy among women. Most of these cancers overexpress cyclin D1, a component of the core cell-cycle machinery. We previously generated mice lacking cyclin D1 using gene targeting. Here we report that these cyclin D1-deficient mice are resistant to breast cancers induced by the neu and ras oncogenes. However, animals lacking cyclin D1 remain fully sensitive to other oncogenic...
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