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Article

Distinct ErbB-2 coupled signaling pathways promote mammary tumors with unique pathologic and transcriptional profiles.

Cancer research - 15 Aug 2007

Schade Babette, Lam Sonya H L, Cernea Daniela, Sanguin-Gendreau Virginie, Cardiff Robert D, Jung Boonim L, Hallett Michael, Muller William J

Abstract excerpt

ErbB-2 overexpression and amplification occurs in 15% to 30% of human invasive breast carcinomas associated with poor clinical prognosis. Previously, we have shown that four ErbB-2/Neu tyrosine-autophosphorylation sites within the cytoplasmic tail of the receptor recruit distinct adaptor proteins and are sufficient to mediate transforming signals in vitro. Two of these sites, representing the growth factor...

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Share to Chemokine CXCL12
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mammary Neoplasms, Experimental

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Share to Receptor, ErbB-2

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Share to Src Homology 2 Domain-Containing, Transforming Protein 1

Source

Identifiers

PMID: 17699761
DOI: 10.1158/0008-5472.CAN-06-4724

Genes

CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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