Article
Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions.
Molecular and cellular biology - 1 Dec 2004
Yang Jiang-Yan, Michod David, Walicki Joël, Murphy Brona M, Kasibhatla Shailaja, Martin Seamus J, Widmann Christian
Abstract excerpt
Tight control of apoptosis is required for proper development and maintenance of homeostasis in multicellular organisms. Cells can protect themselves from potentially lethal stimuli by expressing antiapoptotic factors, such as inhibitors of apoptosis, FLICE (caspase 8)-inhibitory proteins, and members of the Bcl2 family. Here, we describe a mechanism that allows cells to survive once executioner caspases have...
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