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Article

Tuberin activates the proapoptotic molecule BAD.

Oncogene - 19 Oct 2006

Freilinger A, Rosner M, Krupitza G, Nishino M, Lubec G, Korsmeyer S J, Hengstschläger M

Abstract excerpt

TSC1, encoding hamartin, and TSC2, encoding tuberin, are tumor suppressor genes responsible for the autosomal dominantly inherited disease tuberous sclerosis (TSC). TSC affects approximately 1 in 6000 individuals and is characterized by the development of tumors, named hamartomas, in different organs. Hamartin and tuberin form a complex, of which tuberin is assumed to be the functional component. The TSC proteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16702951
DOI: 10.1038/sj.onc.1209660

Genes

BAD
TSC2
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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