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Article

Versatility of BCR/ABL-expressing leukemic cells in circumventing proapoptotic BAD effects.

Blood - 15 Jul 2000

Salomoni P, Condorelli F, Sweeney S M, Calabretta B

Abstract excerpt

BAD, the proapoptotic member of the "BH3-only" subfamily of BCL-2 proteins, is inactivated by phosphorylation at serines 112 and 136 and by sequestration in the cytoplasm where it interacts with members of the 14-3-3 family. In BCR/ABL-expressing cells, BAD is constitutively phosphorylated and mainly cytoplasmic, whereas in cells expressing BCR/ABL mutants unable to protect from apoptosis, BAD is...

Read the complete abstract on PubMed

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Share to bcl-Associated Death Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10887134

Genes

BAD
BCR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Versatility of BCR/ABL-expressing leukemic cells in circumventing proapoptotic BAD effects.PMID 10887134Read ↗

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