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Article

Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.

Molecular and cellular biology - 1 Sept 2003

Chiang Chi-Wu, Kanies Cindy, Kim Kwang Woon, Fang Wei Bin, Parkhurst Christina, Xie Minhui, Henry Travis, Yang Elizabeth

Abstract excerpt

BAD, a proapoptotic molecule of the BCL2 family, is regulated by reversible phosphorylation. During survival, BAD is sequestered by 14-3-3 through serine 136 phosphorylation and is dissociated from BCL-X(L) through serine 155 phosphorylation. We report that phosphoserine 112 (pSer112) dephosphory...

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Share to 14-3-3 Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12944463
DOI: 10.1128/MCB.23.18.6350-6362.2003
PMCID: PMC193703

Genes

BAD
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12944463-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.PMID 12944463Read ↗

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