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Article

JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD.

Molecular cell - 13 Feb 2004

Yu Chenfei, Minemoto Yuzuru, Zhang Jiyan, Liu Jing, Tang Fangming, Bui Truc N, Xiang Jialing, Lin Anning

Abstract excerpt

JNK has been suggested to be proapoptotic, antiapoptotic, or have no role in apoptosis depending on the cell type and stimulus used. The precise mechanism of JNK action, under conditions when it promotes cell survival, is not entirely clear. Here, we report that JNK is required for IL-3-mediated cell survival through phosphorylation and inactivation of the proapoptotic Bcl-2 family protein BAD. IL-3...

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Source

Identifiers

PMID: 14967141
DOI: 10.1016/s1097-2765(04)00028-0

Genes

BAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD.PMID 14967141Read ↗

Novel role for JNK as a stress-activated Bcl2 kinase.Semantic proximity Read ↗

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.Semantic proximity Read ↗

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins.Semantic proximity Read ↗

Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions.Semantic proximity Read ↗

Caspase-3 protects stressed organs against cell death.Semantic proximity Read ↗

From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical ImportanceSemantic proximity Read ↗

14-3-3 inhibits Bad-induced cell death through interaction with serine-136.Semantic proximity Read ↗

Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034.Semantic proximity Read ↗

Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1.Semantic proximity Read ↗

The proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2.Semantic proximity Read ↗

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.Semantic proximity Read ↗

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.Semantic proximity Read ↗

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