Inducible Gene Knockouts in the Small Intestinal and Colonic Epithelium

doi:10.1074/jbc.274.53.38071

Article

Inducible Gene Knockouts in the Small Intestinal and Colonic Epithelium

1 Dec 1999

Abstract excerpt

We have developed two systems for performing Cre-mediated recombination of target genes in the rapidly self-renewing mouse small intestinal and colonic epithelium. When expression of Cre recombinase is placed directly under the control of transcriptional regulatory elements from a fatty acid-binding protein gene (Fabp), deletion of loxP flanked (floxed) DNA sequences is initiated as early as embryonic day 13.5,...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.