Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.

Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2016

Tetteh Paul W, Kretzschmar Kai, Begthel Harry, van den Born Maaike, Korving Jeroen, Morsink Folkert, Farin Henner, van Es Johan H, Offerhaus G Johan A, Clevers Hans

Abstract excerpt

Current mouse models for colorectal cancer often differ significantly from human colon cancer, being largely restricted to the small intestine. Here, we aim to develop a colon-specific inducible mouse model that can faithfully recapitulate human colon cancer initiation and progression. Carbonic anhydrase I (Car1) is a gene expressed uniquely in colonic epithelial cells. We generated a colon-specific inducible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knock-In Techniques

Share to Gene Targeting

Share to Genes, APC

Share to Integrases

Share to Intestinal Mucosa

Share to Organ Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 27708166
DOI: 10.1073/pnas.1614057113
PMCID: PMC5081651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.PMID 27708166Read ↗

Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras.Semantic proximity Read ↗

Genetically induced mouse model for colon-specific epithelial cell tumorigenesis driven by loss of K8 and ApcSemantic proximity Read ↗

Mouse models of intestinal cancer.Semantic proximity Read ↗

Mouse models for the discovery of colorectal cancer driver genes.Semantic proximity Read ↗

Development and Characterization of a Genetic Mouse Model of KRAS Mutated Colorectal Cancer.Semantic proximity Read ↗

Mouse Models for Application in Colorectal Cancer: Understanding the Pathogenesis and Relevance to the Human ConditionSemantic proximity Read ↗

Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations.Semantic proximity Read ↗

Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.Semantic proximity Read ↗

A Novel CRISPR/Cas9-mediated Mouse Model of Colon Carcinogenesis.Semantic proximity Read ↗

Mouse models of colorectal cancerSemantic proximity Read ↗

Mouse models for the study of colon carcinogenesis.Semantic proximity Read ↗

Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.