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Article

Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice.

The Journal of clinical investigation - 15 Oct 1996

Vyse T J, Drake C G, Rozzo S J, Roper E, Izui S, Kotzin B L

Abstract excerpt

F1 hybrids of New Zealand black (NZB) and New Zealand white (NZW) mice are a model of human systemic lupus erythematosus. These mice develop a severe immune com-plex-mediated nephritis, in which antinuclear autoantibodies are believed to play the major role. We used a genetic analysis of (NZB x N...

Topics

Alleles
Animals
Antibodies, Antinuclear
Autoantibodies
Chromosome Mapping
Genetic Linkage
Glycoproteins
Immunoglobulin G
Lupus Nephritis
Mice
Mice, Inbred NZB
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8878426
DOI: 10.1172/JCI118975
PMCID: PMC507614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8878426-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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