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Article

The role of the C-terminal domain in the inhibitory functions of tissue factor pathway inhibitor.

FEBS letters - 17 Dec 1999

Ettelaie C, Adam J M, James N J, Oke A O, Harrison J A, Bunce T D, Bruckdorfer K R

Abstract excerpt

Tissue factor pathway inhibitor (TFPI) inhibits the activity of coagulation factors VIIa and Xa through Kunitz domains, thereby inhibiting the activity of tissue factor. However, it has been shown that the C-terminal of this inhibitor is essential for the maximal anticoagulant activity of TFPI. We have investigated the endogenous ability of the C-terminal of TFPI to influence coagulation. A synthetic peptide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10606750
DOI: 10.1016/s0014-5793(99)01663-4

Genes

TFPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of the C-terminal domain in the inhibitory functions of tissue factor pathway inhibitor.PMID 10606750Read ↗

New insights into the biology of tissue factor pathway inhibitor.Semantic proximity Read ↗

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Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2.Semantic proximity Read ↗

Tissue factor residues Lys165 and Lys166 are essential for rapid formation of the quaternary complex of tissue factor.VIIa with Xa.tissue factor pathway inhibitor.Semantic proximity Read ↗

Functional characterization of polymorphisms in the human TFPI gene.Semantic proximity Read ↗

Inhibitory effects of TFPI variants on thrombin and factor Xa generation in fibrinogen-deficient human plasma.Semantic proximity Read ↗

Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice.Semantic proximity Read ↗

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A new T-287C polymorphism in the 5' regulatory region of the tissue factor pathway inhibitor gene. Association study of the T-287C and C-399T polymorphisms with coronary artery disease and plasma TFPI levels.Semantic proximity Read ↗

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