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Article

Expression and characterization of wild-type TFPI and the [P151L]TFPI mutant in insect cells.

Molecular and cellular biochemistry - 1 Feb 2006

Thyzel Elmar, Siegling Sabine, Brinkmann Thomas, Kleesiek Knut, Götting Christian

Abstract excerpt

Tissue factor pathway inhibitor (TFPI) is a multivalent Kunitz-type serine proteinase inhibitor that plays a central role in the extrinsic pathway of blood coagulation. In earlier studies we could identify the [P151L]TFPI mutant, and we could also demonstrate that heterozygous carriers of this mutant show a nine-fold increased risk for deep venous thrombosis (DVT). To express greater amounts of both proteins and...

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Source

Identifiers

PMID: 16444583
DOI: 10.1007/s11010-006-2267-9

Genes

TFPI

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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