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Article

Functional characterization of polymorphisms in the human TFPI gene.

Biochemical and biophysical research communications - 18 Jun 2010

Skretting Grethe, Stavik Benedicte, Landvik Nina E, Myklebust Christiane F, Iversen Nina, Zienolddiny Shan, Sandset Per Morten

Abstract excerpt

Tissue factor pathway inhibitor (TFPI) is the primary physiological inhibitor of tissue factor (TF) induced coagulation. Low plasma TFPI levels have been shown to be associated with increased risk of arterial and venous thrombosis. Several clinical studies have reported that single nucleotide polymorphisms (SNPs) in the regulatory regions of the gene, such as the -287T/C, the -399C/T, and the -33T/C SNPs, may...

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Identifiers

PMID: 20519147
DOI: 10.1016/j.bbrc.2010.05.078

Genes

TFPI

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Related research

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Functional characterization of polymorphisms in the human TFPI gene.PMID 20519147Read ↗

A new T-287C polymorphism in the 5' regulatory region of the tissue factor pathway inhibitor gene. Association study of the T-287C and C-399T polymorphisms with coronary artery disease and plasma TFPI levels.Semantic proximity Read ↗

Analysis of a T-287C polymorphism in the tissue factor pathway inhibitor gene and identification of a repressor element in the promoter.Semantic proximity Read ↗

Tissue factor pathway inhibitor polymorphisms in women with and without a history of venous thrombosis and the effects of postmenopausal hormone therapy.Semantic proximity Read ↗

Genetic determinants of tissue factor pathway inhibitor plasma levels.Semantic proximity Read ↗

Polymorphisms of the tissue factor pathway inhibitor gene are associated with venous thromboembolism in the antiphospholipid syndrome and carriers of factor V Leiden.Semantic proximity Read ↗

Significant genetic association of a functional TFPI variant with circulating fibrinogen levels and coronary artery disease.Semantic proximity Read ↗

Genetic polymorphisms and plasma levels of tissue factor and tissue factor pathway inhibitor in venous thromboembolism.Semantic proximity Read ↗

Analysis of sequence variations in the promoter region of the human tissue factor pathway inhibitor 2 gene in apoplectic patients and blood donors.Semantic proximity Read ↗

The 536C→T Transition in the Human Tissue Factor Pathway Inhibitor (TFPI) Gene Is Statistically Associated with a Higher Risk for Venous ThrombosisSemantic proximity Read ↗

The -33T-->C polymorphism in intron 7 of the TFPI gene influences the risk of venous thromboembolism, independently of the factor V Leiden and prothrombin mutations.Semantic proximity Read ↗

Polymorphisms in the tissue factor pathway inhibitor gene are not associated with ischaemic stroke.Semantic proximity Read ↗

Mutations in Promoter Region of Thrombomodulin and Venous Thromboembolic DiseaseSemantic proximity Read ↗

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