Tissue factor residues Lys165 and Lys166 are essential for rapid formation of the quaternary complex of tissue factor.VIIa with Xa.tissue factor pathway inhibitor.

doi:10.1021/bi00034a020

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Article

Tissue factor residues Lys165 and Lys166 are essential for rapid formation of the quaternary complex of tissue factor.VIIa with Xa.tissue factor pathway inhibitor.

Biochemistry - 29 Aug 1995

Rao L V, Ruf W

Abstract excerpt

The extrinsic coagulation pathway is initiated by the binding of plasma factor VII(a) (VIIa) to the cell surface receptor tissue factor (TF), which serves as the cofactor for the ligand protease VIIa in the activation of macromolecular substrate factors X and IX. The catalytic function of the TF....

Topics

Blood Coagulation
Factor VIIa
Factor X
Factor Xa
Humans
Kinetics
Lipoproteins
Lysine
Mutation
Protein Binding
Protein Conformation
Recombinant Proteins
Subtilisins
Thromboplastin

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