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Article

Tissue factor residues Lys165 and Lys166 are essential for rapid formation of the quaternary complex of tissue factor.VIIa with Xa.tissue factor pathway inhibitor.

Biochemistry - 29 Aug 1995

Rao L V, Ruf W

Abstract excerpt

The extrinsic coagulation pathway is initiated by the binding of plasma factor VII(a) (VIIa) to the cell surface receptor tissue factor (TF), which serves as the cofactor for the ligand protease VIIa in the activation of macromolecular substrate factors X and IX. The catalytic function of the TF.VIIa complex is regulated by a specific Kunitz-type inhibitor, tissue factor pathway inhibitor (TFPI), which forms a...

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Identifiers

PMID: 7662667
DOI: 10.1021/bi00034a020

Genes

TFPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Tissue factor residues Lys165 and Lys166 are essential for rapid formation of the quaternary complex of tissue factor.VIIa with Xa.tissue factor pathway inhibitor.PMID 7662667Read ↗

Molecular interaction between factor VII and tissue factor.Semantic proximity Read ↗

Influence of mutations in tissue factor on the fine specificity of macromolecular substrate activation.Semantic proximity Read ↗

Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant.Semantic proximity Read ↗

Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitor.Semantic proximity Read ↗

Tissue Factor residue Asp44 regulates catalytic function of the bound proteinase Factor VIIa.Semantic proximity Read ↗

Tissue factor residues that putatively interact with membrane phospholipids.Semantic proximity Read ↗

The first epidermal growth factor-like domains of factor Xa and factor IXa are important for the activation of the factor VII--tissue factor complex.Semantic proximity Read ↗

New insights into the biology of tissue factor pathway inhibitor.Semantic proximity Read ↗

In vivo activation and functions of the protease factor XIISemantic proximity Read ↗

Identification of the factor XII contact activation site enables sensitive coagulation diagnostics.Semantic proximity Read ↗

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.Semantic proximity Read ↗

A frequent human coagulation Factor VII mutation (A294V, c152) in loop 140s affects the interaction with activators, tissue factor and substrates.Semantic proximity Read ↗

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