Inhibitory effects of TFPI variants on thrombin and factor Xa generation in fibrinogen-deficient human plasma.

doi:10.1016/0049-3848(94)90285-2

Back to search

Article

Inhibitory effects of TFPI variants on thrombin and factor Xa generation in fibrinogen-deficient human plasma.

Thrombosis research - 15 Dec 1994

Kaiser B, Jeske W, Hoppensteadt D, Fareed J

Abstract excerpt

Using a fast kinetic centrifugal analyzer, the inhibitory effects of glycosylated and unglycosylated full-length and truncated forms of TFPI on protease generation were studied in fibrinogen-deficient human plasma after extrinsic (EA) or intrinsic (IA) activation of coagulation. When the assay sy...

Topics

Afibrinogenemia
Anticoagulants
Factor Xa
Genetic Variation
Humans
Lipoproteins
Structure-Activity Relationship
Thrombin

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.