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Article

Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice.

Blood - 1 Aug 1997

Huang Z F, Higuchi D, Lasky N, Broze G J

Abstract excerpt

Tissue factor pathway inhibitor (TFPI) is a multivalent Kunitz-type proteinase inhibitor that directly inhibits factor Xa and, in a factor Xa-dependent fashion, produces feedback inhibition of the factor VIIa/TF catalytic complex responsible for the initiation of coagulation. To further define th...

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Source

Identifiers

PMID: 9242522

Genes

TFPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9242522-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice.PMID 9242522Read ↗

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New insights into the biology of tissue factor pathway inhibitor.Semantic proximity Read ↗

Gene targeting of tissue factor, factor X, and factor VII in mice: their involvement in embryonic development.Semantic proximity Read ↗

Combined tissue factor pathway inhibitor and thrombomodulin deficiency produces an augmented hypercoagulable state with tissue-specific fibrin deposition.Semantic proximity Read ↗

Prothrombin deficiency results in embryonic and neonatal lethality in mice.Semantic proximity Read ↗

Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice.Semantic proximity Read ↗

Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia.Semantic proximity Read ↗

Gene targeting of components of the fibrinolytic system.Semantic proximity Read ↗

Placental Vascular Defects and Embryonic Lethality Triggered by TFPIα Deficiency in Factor V Leiden Mice.Semantic proximity Read ↗

Consequences of tissue factor pathway inhibitor gene-disruption in mice.Semantic proximity Read ↗

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