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Article

Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues.

The American journal of pathology - 1 Nov 1998

Jiménez-Huete A, Lievens P M, Vidal R, Piccardo P, Ghetti B, Tagliavini F, Frangione B, Prelli F

Abstract excerpt

We have investigated the proteolytic cleavage of the cellular (PrPC) and pathological (PrPSc) isoforms of the human prion protein (PrP) in normal and prion-affected brains and in tonsils and platelets from neurologically intact individuals. The various PrP species were resolved after deglycosylation according to their electrophoretic mobility, immunoreactivity, Sarkosyl solubility, and, as a novel approach,...

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Identifiers

PMID: 9811348
DOI: 10.1016/S0002-9440(10)65744-6
PMCID: PMC1853409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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