Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues.

doi:10.1016/S0002-9440(10)65744-6

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Article

Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues.

The American journal of pathology - 1 Nov 1998

Jiménez-Huete A, Lievens P M, Vidal R, Piccardo P, Ghetti B, Tagliavini F, Frangione B, Prelli F

Abstract excerpt

We have investigated the proteolytic cleavage of the cellular (PrPC) and pathological (PrPSc) isoforms of the human prion protein (PrP) in normal and prion-affected brains and in tonsils and platelets from neurologically intact individuals. The various PrP species were resolved after deglycosylat...

Topics

Aged
Alzheimer Disease
Blood Platelets
Brain
Brain Chemistry
Codon
Creutzfeldt-Jakob Syndrome
Genotype
Gerstmann-Straussler-Scheinker Disease
Glycosylation
Humans
Metalloendopeptidases
Middle Aged
Neurons

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Palatine Tonsil

Peptide Fragments

Peptide Mapping

PrPC Proteins

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Identifiers

PMID: 9811348
DOI: 10.1016/S0002-9440(10)65744-6
PMCID: PMC1853409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9811348-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.