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Article

Functionally relevant domains of the prion protein identified in vivo.

PloS one - 7 Sept 2009

Baumann Frank, Pahnke Jens, Radovanovic Ivan, Rülicke Thomas, Bremer Juliane, Tolnay Markus, Aguzzi Adriano

Abstract excerpt

The prion consists essentially of PrP(Sc), a misfolded and aggregated conformer of the cellular protein PrP(C). Whereas PrP(C) deficient mice are clinically healthy, expression of PrP(C) variants lacking its central domain (PrP(DeltaCD)), or of the PrP-related protein Dpl, induces lethal neurodegenerative syndromes which are repressed by full-length PrP. Here we tested the structural basis of these syndromes by...

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Source

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Identifiers

PMID: 19738901
DOI: 10.1371/journal.pone.0006707
PMCID: PMC2733036

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GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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