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Article

Increased power to detect gene-environment interaction using siblings controls.

Annals of epidemiology - 1 Oct 2005

Andrieu Nadine, Dondon Marie-Gabrielle, Goldstein Alisa M

Abstract excerpt

PURPOSE: Interest is increasing in studying gene-environment (G x E) interaction in disease etiology. Study designs using related controls as a more appropriate control group for evaluating G x E interactions have been proposed but often assume unrealistic numbers of available relative controls. To evaluate a more realistic design, we studied the relative efficiency of a 1:0.5 case-sibling-control design compared...

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Identifiers

PMID: 16157257
DOI: 10.1016/j.annepidem.2005.01.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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